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Fluka Chemical n-methylmorpholine (nmm)
N Methylmorpholine (Nmm), supplied by Fluka Chemical, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Article Title: Non-nucleic acid probes, probe sets, methods and kits pertaining to the detection of individual human chromosomes X, Y, 1, 2, 3, 4, 6, 7, 8, 9, 10, 11, 12, 16, 17, 18 and 20 as 13/21 as a pair
Article Snippet: To 70 mmol of bis-(2-methoxyethyl)amidyl-diglycolic acid was added 120 mL of anhydrous acetonitrile (Fluka Chemical), 240 mmol of N-methylmorpholine (NMM; Fluka Chemical) and 75 mmol of trimethylacetyl chloride (Aldrich Chemical).

Article Title: Compositions comprising a linked acceptor moiety
Article Snippet: To 9 mmol of N,N′-[bis-(2-methoxyethyl])-glycine was added 20 mL of anhydrous acetonitrile (Fluka Chemical), 9 mmol diisopropylethylamine (DIEA, Aldrich Chemical), 27 mmol of N-methylmorpholine (NMM; Fluka Chemical) and 9.3 mmol of trimethylacetyl chloride (Aldrich Chemical).

Article Title: Compositions comprising a linked acceptor moiety
Article Snippet: To 70 mmol of bis-(2-methoxyethyl)amidyl-diglycolic acid was added 120 mL of anhydrous acetonitrile (Fluka Chemical), 240 mmol of N-methylmorpholine (NMM; Fluka Chemical) and 75 mmol of trimethylacetyl chloride (Aldrich Chemical).

Article Title: Copper(II) complexes of Neb-colloostatin and of (P4A) analogue Stability Structure Apoptosis
Article Snippet: The nineteenth amino acid peptide Neb-colloostatin SIVPLGLPVPIGPIVVGPR and its analogue with point mutation (P4A) were synthesized and their copper(II) complexes were studied by potentiometric, UV– Vis, circular dichroism (CD), and electron paramagnetic resonance (EPR) spectroscopic methods.. The amine-N nitrogen atoms of serine residues were found to be the primary metal binding sites of both peptides.. These binding modes provide the deprotonation and coordination of two amide nitrogens of the Neb-colloostatin and the formation of the 3N {NH2,2N ,CO} complex at pH 7.5–8.

Article Title: Ultrashort Peptide Bioconjugates Are Exclusively Antifungal Agents and Synergize with Cyclodextrin and Amphotericin B
Article Snippet: Other reagents used for peptide synthesis included trifluoroacetic acid (TFA; Sigma), piperidine (Merck), N,Ndiisopropylethylamine (DIEA; Sigma), N-methylmorpholine (NMM; Fluka), N-hydroxybenzotriazole hydrate (HOBT; Aldrich), 2-(1Hbenzotriazol-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate (HBTU), and dimethylformamide (DMF peptide synthesis grade; Biolab).

Article Title: Effects of peptide backbone amide-to-ester bond substitution on the cleavage frequency in electron capture dissociation and collision-activated dissociation.
Article Snippet: Coupling was catalyzed by N-methylmorpholine (NMM) (Fluka, Buchs SG, Switzerland) in N,N-dimethylformamide (DMF) (Fluka).

Article Title: A post-modification approach to peptide foldamers.
Article Snippet: Hydrophilic/hydrophobic patterning is a powerful strategy to control folding in non-natural polymers/oligomers.. In this contribution, we present a novel strategy for the preparation of alternating hydrophilic/hydrophobic patterned non-natural peptide foldamers.. This strategy relies on the post-modification of a reactive peptide precursor that can be prepared via standard solid phase peptide synthesis without the need for side chain protective groups.

Article Title: Ultrashort Peptide Bioconjugates Are Exclusively Antifungal Agents and Synergize with Cyclodextrin and Amphotericin B
Article Snippet: Other reagents used for peptide synthesis included trifluoroacetic acid (TFA; Sigma), piperidine (Merck), N , N -diisopropylethylamine (DIEA; Sigma), N -methylmorpholine (NMM; Fluka), N -hydroxybenzotriazole hydrate (HOBT; Aldrich), 2-(1 H -benzotriazol-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate (HBTU), and dimethylformamide (DMF peptide synthesis grade; Biolab).



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(A) Digital image of Fmoc-amino acid in the presence of 1-Ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDC.HCl) and Oxyma prior to aqueous activation. (B) Fmoc-amino acid with EDC.HCl and <t>Oxyma,</t> <t>N-methylmorpholine</t> <t>(NMM),</t> in water mixed manually, showing incomplete dissolution and visible undissolved particulates. (C) The same mixture subjected to ultrasonic agitation at ambient temperature for 10 min, exhibiting persistent phase heterogeneity and incomplete solubilization. (D) Mixture heated to ∼50 °C with manual stirring, showing partial dispersion but continued presence of undissolved material. (E) Mixture heated to ∼50 °C and simultaneously subjected to ultrasonic irradiation for 10 min, resulting in a homogeneous yellow solution, indicating complete dissolution in water.
N Methylmorpholine Nmm, supplied by Loba Chemie, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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(A) Digital image of Fmoc-amino acid in the presence of 1-Ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDC.HCl) and Oxyma prior to aqueous activation. (B) Fmoc-amino acid with EDC.HCl and <t>Oxyma,</t> <t>N-methylmorpholine</t> <t>(NMM),</t> in water mixed manually, showing incomplete dissolution and visible undissolved particulates. (C) The same mixture subjected to ultrasonic agitation at ambient temperature for 10 min, exhibiting persistent phase heterogeneity and incomplete solubilization. (D) Mixture heated to ∼50 °C with manual stirring, showing partial dispersion but continued presence of undissolved material. (E) Mixture heated to ∼50 °C and simultaneously subjected to ultrasonic irradiation for 10 min, resulting in a homogeneous yellow solution, indicating complete dissolution in water.
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(A) Digital image of Fmoc-amino acid in the presence of 1-Ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDC.HCl) and Oxyma prior to aqueous activation. (B) Fmoc-amino acid with EDC.HCl and <t>Oxyma,</t> <t>N-methylmorpholine</t> <t>(NMM),</t> in water mixed manually, showing incomplete dissolution and visible undissolved particulates. (C) The same mixture subjected to ultrasonic agitation at ambient temperature for 10 min, exhibiting persistent phase heterogeneity and incomplete solubilization. (D) Mixture heated to ∼50 °C with manual stirring, showing partial dispersion but continued presence of undissolved material. (E) Mixture heated to ∼50 °C and simultaneously subjected to ultrasonic irradiation for 10 min, resulting in a homogeneous yellow solution, indicating complete dissolution in water.
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(A) Digital image of Fmoc-amino acid in the presence of 1-Ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDC.HCl) and Oxyma prior to aqueous activation. (B) Fmoc-amino acid with EDC.HCl and <t>Oxyma,</t> <t>N-methylmorpholine</t> <t>(NMM),</t> in water mixed manually, showing incomplete dissolution and visible undissolved particulates. (C) The same mixture subjected to ultrasonic agitation at ambient temperature for 10 min, exhibiting persistent phase heterogeneity and incomplete solubilization. (D) Mixture heated to ∼50 °C with manual stirring, showing partial dispersion but continued presence of undissolved material. (E) Mixture heated to ∼50 °C and simultaneously subjected to ultrasonic irradiation for 10 min, resulting in a homogeneous yellow solution, indicating complete dissolution in water.
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(A) Digital image of Fmoc-amino acid in the presence of 1-Ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDC.HCl) and Oxyma prior to aqueous activation. (B) Fmoc-amino acid with EDC.HCl and <t>Oxyma,</t> <t>N-methylmorpholine</t> <t>(NMM),</t> in water mixed manually, showing incomplete dissolution and visible undissolved particulates. (C) The same mixture subjected to ultrasonic agitation at ambient temperature for 10 min, exhibiting persistent phase heterogeneity and incomplete solubilization. (D) Mixture heated to ∼50 °C with manual stirring, showing partial dispersion but continued presence of undissolved material. (E) Mixture heated to ∼50 °C and simultaneously subjected to ultrasonic irradiation for 10 min, resulting in a homogeneous yellow solution, indicating complete dissolution in water.
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(A) Digital image of Fmoc-amino acid in the presence of 1-Ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDC.HCl) and Oxyma prior to aqueous activation. (B) Fmoc-amino acid with EDC.HCl and <t>Oxyma,</t> <t>N-methylmorpholine</t> <t>(NMM),</t> in water mixed manually, showing incomplete dissolution and visible undissolved particulates. (C) The same mixture subjected to ultrasonic agitation at ambient temperature for 10 min, exhibiting persistent phase heterogeneity and incomplete solubilization. (D) Mixture heated to ∼50 °C with manual stirring, showing partial dispersion but continued presence of undissolved material. (E) Mixture heated to ∼50 °C and simultaneously subjected to ultrasonic irradiation for 10 min, resulting in a homogeneous yellow solution, indicating complete dissolution in water.
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(A) Digital image of Fmoc-amino acid in the presence of 1-Ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDC.HCl) and Oxyma prior to aqueous activation. (B) Fmoc-amino acid with EDC.HCl and <t>Oxyma,</t> <t>N-methylmorpholine</t> <t>(NMM),</t> in water mixed manually, showing incomplete dissolution and visible undissolved particulates. (C) The same mixture subjected to ultrasonic agitation at ambient temperature for 10 min, exhibiting persistent phase heterogeneity and incomplete solubilization. (D) Mixture heated to ∼50 °C with manual stirring, showing partial dispersion but continued presence of undissolved material. (E) Mixture heated to ∼50 °C and simultaneously subjected to ultrasonic irradiation for 10 min, resulting in a homogeneous yellow solution, indicating complete dissolution in water.
N Methylmorpholine (Nmm, Catalog # M0370, Cas # 109–02 4), supplied by Tokyo Chemical Industry, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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(A) Digital image of Fmoc-amino acid in the presence of 1-Ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDC.HCl) and Oxyma prior to aqueous activation. (B) Fmoc-amino acid with EDC.HCl and <t>Oxyma,</t> <t>N-methylmorpholine</t> <t>(NMM),</t> in water mixed manually, showing incomplete dissolution and visible undissolved particulates. (C) The same mixture subjected to ultrasonic agitation at ambient temperature for 10 min, exhibiting persistent phase heterogeneity and incomplete solubilization. (D) Mixture heated to ∼50 °C with manual stirring, showing partial dispersion but continued presence of undissolved material. (E) Mixture heated to ∼50 °C and simultaneously subjected to ultrasonic irradiation for 10 min, resulting in a homogeneous yellow solution, indicating complete dissolution in water.
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Fluka Chemical n-methylmorpholine (nmm)
(A) Digital image of Fmoc-amino acid in the presence of 1-Ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDC.HCl) and Oxyma prior to aqueous activation. (B) Fmoc-amino acid with EDC.HCl and <t>Oxyma,</t> <t>N-methylmorpholine</t> <t>(NMM),</t> in water mixed manually, showing incomplete dissolution and visible undissolved particulates. (C) The same mixture subjected to ultrasonic agitation at ambient temperature for 10 min, exhibiting persistent phase heterogeneity and incomplete solubilization. (D) Mixture heated to ∼50 °C with manual stirring, showing partial dispersion but continued presence of undissolved material. (E) Mixture heated to ∼50 °C and simultaneously subjected to ultrasonic irradiation for 10 min, resulting in a homogeneous yellow solution, indicating complete dissolution in water.
N Methylmorpholine (Nmm), supplied by Fluka Chemical, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Image Search Results


(A) Digital image of Fmoc-amino acid in the presence of 1-Ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDC.HCl) and Oxyma prior to aqueous activation. (B) Fmoc-amino acid with EDC.HCl and Oxyma, N-methylmorpholine (NMM), in water mixed manually, showing incomplete dissolution and visible undissolved particulates. (C) The same mixture subjected to ultrasonic agitation at ambient temperature for 10 min, exhibiting persistent phase heterogeneity and incomplete solubilization. (D) Mixture heated to ∼50 °C with manual stirring, showing partial dispersion but continued presence of undissolved material. (E) Mixture heated to ∼50 °C and simultaneously subjected to ultrasonic irradiation for 10 min, resulting in a homogeneous yellow solution, indicating complete dissolution in water.

Journal: bioRxiv

Article Title: Thermal-Acoustic Activation of Hydrophobic Polystyrene Supports for High-Efficiency Aqueous Solid-Phase Peptide Synthesis

doi: 10.64898/2026.05.05.722603

Figure Lengend Snippet: (A) Digital image of Fmoc-amino acid in the presence of 1-Ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDC.HCl) and Oxyma prior to aqueous activation. (B) Fmoc-amino acid with EDC.HCl and Oxyma, N-methylmorpholine (NMM), in water mixed manually, showing incomplete dissolution and visible undissolved particulates. (C) The same mixture subjected to ultrasonic agitation at ambient temperature for 10 min, exhibiting persistent phase heterogeneity and incomplete solubilization. (D) Mixture heated to ∼50 °C with manual stirring, showing partial dispersion but continued presence of undissolved material. (E) Mixture heated to ∼50 °C and simultaneously subjected to ultrasonic irradiation for 10 min, resulting in a homogeneous yellow solution, indicating complete dissolution in water.

Article Snippet: N, N’ -diisopropylethylamine (DIPEA) (CAS Number: 387649), N-methylmorpholine (NMM) (CAS Number: 109-02-4), piperedine (PIP) (CAS Number: 110-89-4), (Acetic anhydride (CAS Number: 108-24-7) acetonitrile (ACN) (CAS Number: 75-05-8), methanol (MeOH) (CAS Number: 67-56-1), isopropyl alcohol (IPA) (CAS Number: 67-63-0), N, N’ -dimethylformamide (DMF) (CAS Number: 68-12-2), dichloromethane (DCM) (CAS Number: 75-09-2), trifluoroacetic acid (TFA) (CAS Number: 76-05-1), triisopropylsilane (TIS) (CAS Number: T1533), diethyl ether (CAS Number: 60-29-7), and tert-butyl methyl ether (CAS Number: 1634-04-4) were obtained from Loba Chemie Private Limited.

Techniques: Activation Assay, Dissolution, Dispersion, Irradiation

Schematic representation of the coupling mechanism of Fmoc-protected amino acids on 2-chlorotrityl chloride (2-CTC) polystyrene resin under thermal–acoustic conditions. Initially, N -Methylmorpholine (NMM) is dissolved in water ( Step-1 ), and the Fmoc-amino acid is further dissolved in this mixture under heating and ultrasonic irradiation, generating a homogeneous aqueous solution ( Step-2 ). Upon addition of EDC·HCl, the carboxylate group is activated to form an O -acylisourea intermediate ( Step-3 ), which is subsequently stabilized by Oxyma to produce a reactive active ester ( Step-4 ). Under thermal–acoustic conditions, the activated ester diffuses into the hydrophobic resin matrix and reacts with the free amine ( Step-5 ), resulting in amide bond formation and extension of the peptide chain ( Step-6 ).

Journal: bioRxiv

Article Title: Thermal-Acoustic Activation of Hydrophobic Polystyrene Supports for High-Efficiency Aqueous Solid-Phase Peptide Synthesis

doi: 10.64898/2026.05.05.722603

Figure Lengend Snippet: Schematic representation of the coupling mechanism of Fmoc-protected amino acids on 2-chlorotrityl chloride (2-CTC) polystyrene resin under thermal–acoustic conditions. Initially, N -Methylmorpholine (NMM) is dissolved in water ( Step-1 ), and the Fmoc-amino acid is further dissolved in this mixture under heating and ultrasonic irradiation, generating a homogeneous aqueous solution ( Step-2 ). Upon addition of EDC·HCl, the carboxylate group is activated to form an O -acylisourea intermediate ( Step-3 ), which is subsequently stabilized by Oxyma to produce a reactive active ester ( Step-4 ). Under thermal–acoustic conditions, the activated ester diffuses into the hydrophobic resin matrix and reacts with the free amine ( Step-5 ), resulting in amide bond formation and extension of the peptide chain ( Step-6 ).

Article Snippet: N, N’ -diisopropylethylamine (DIPEA) (CAS Number: 387649), N-methylmorpholine (NMM) (CAS Number: 109-02-4), piperedine (PIP) (CAS Number: 110-89-4), (Acetic anhydride (CAS Number: 108-24-7) acetonitrile (ACN) (CAS Number: 75-05-8), methanol (MeOH) (CAS Number: 67-56-1), isopropyl alcohol (IPA) (CAS Number: 67-63-0), N, N’ -dimethylformamide (DMF) (CAS Number: 68-12-2), dichloromethane (DCM) (CAS Number: 75-09-2), trifluoroacetic acid (TFA) (CAS Number: 76-05-1), triisopropylsilane (TIS) (CAS Number: T1533), diethyl ether (CAS Number: 60-29-7), and tert-butyl methyl ether (CAS Number: 1634-04-4) were obtained from Loba Chemie Private Limited.

Techniques: Irradiation